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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and participants from different geographical regions. This kind of heterogeneity is essential for pragmatic trials to be valid and also reduces bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.
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Legality
Pragmatic Play is known for its top-notch games, and for providing a superior user experience. Its software is designed to work with mobile devices and supports multiple languages. It has established itself as one of the most popular gaming platforms in the casino industry despite its relatively young age. Wolves is one of its latest releases which is a five-reel slot machine with a healthy RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually ordered by policymakers and practitioners in order to inform their decisions. They can also be used to determine the causal relationship between an intervention and its results. However, they should not be used as a substitute for explanation studies.
The concept of pragmatism is controversial and there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they should be an alternative to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study that includes the recruitment, design, and delivery of the intervention and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.